Soursop tree (Annona muricata), grafted on pond apple (Annona glabra) root stock, has confirmed its position on salty soil acidification, due to its easy growing, high yield stability. Recently, fruit rot diseases, soft brown black spots and lesions with hard black cracking on the fruit surface, are big problems for farmers because of productivity losses. The two fungi were isolated, reinoculated to the fruits following Koch postulate and were identified as Lasiodiplodia pseudotheobromae and Colletotrichum gloeosporioides referring to morphological characteristics, gene sequencing results and Blast Search. In in-vitro conditions, the many chemicals as active ingredients Mancozeb + Matalaxyl (Ridomyl), Difenoconazole (Score), Carbendazim (Vicarben) and Thiophanate Methyl (Topsin) were able to inhibit the growth of the fungi and C. gloeosporioides and L. pseudotheobromae from 73.3 percent to 100 percent at the right level of 50 ppm. Out of the five different botanicals tested, the completely inhibit the growth of C. gloeosporioides and L. pseudotheobromae was obtained with the use of Datura metel extract.