KẾT QUẢ ĐIỀU TRỊ UNG THƯ TUYẾN GIÁP THỂ BIỆT HÓA DI CĂN PHỔI BẰNG I-131 TẠI BỆNH VIỆN UNG BƯỚU NGHỆ AN=Treatment results of differentiated thyroid cancer with lung metastasis using I-131 at Nghe An Oncology Hospital

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Tác giả: HồNg Sơn Mai, TrọNg Khoa Mai, NgọC ThắNg NguyễN, Văn HộI NguyễN

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Điện quang và Y học hạt nhân Việt Nam, 2024

Mô tả vật lý: tr.31-40

Bộ sưu tập: Metadata

ID: 486861

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Mục tiêu: Đánh giá kết quả điều trị ung thư tuyến giáp thể biệt hóa di căn phổi điều trị I-131 tại bệnh viện Ung bướu Nghệ An.Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả hồi cứu kết hợp tiến cứu 45 bệnh nhân ung thư tuyến giáp thể biệt hóa di căn phổi được chẩn đoán bằng xạ hình toàn thân và đánh giá kết quả điều trị bằng I-131 tại khoa Y học hạt nhân, bệnh viện Ung bướu Nghệ An từ tháng 1/2018 đến 5/2024.Kết quả: Bệnh nhân ung thư tuyến giáp thể biệt hóa di căn phổi có tuổi trung bình là 47,26 ± 15,75 tuổi, tỷ lệ nam nữ là 1/2,5. Thể giải phẫu bệnh chiếm chủ yếu là thể nhú với tỷ lệ 93,3%. Thyroglobulin lúc ngừng thuốc trung bình là 112,32 ± 154,7 ng/ml. Tổn thương trên xạ hình toàn thân với I-131 chủ yếu dạng tăng hoạt tính phóng xạ lan tỏa với tỷ lệ 77,8%. Bệnh nhân được điều trị nhiều lần với I-131, trung bình 3,75 lần và có tổng liều điều trị tích lũy 540 ± 193,73 mCi (150-970). Tỷ lệ đáp ứng hoàn toàn với I-131 chiếm 17,8%. Tỷ lệ đáp ứng không hoàn toàn và không xác định lần lượt là 64,44%, 17,8%. Tuổi và thyroglobulin kích thích là hai yếu tố có giá trị trong tiên lượng với đáp ứng điều trị I-131 ở bệnh nhân UTTG thể biệt hóa di căn phổi.Kết luận: Bệnh nhân ung thư tuyến giáp thể biệt hóa di căn phổi được điều trị I-131 tại bệnh viện Ung bướu Nghệ An có tỷ lệ đáp ứng hoàn toàn là 17,8
tỷ lệ đáp ứng không hoàn toàn, không xác định lần lượt là 64,44% và 17,8%.Objective: Evaluate the treatment results of differentiated thyroid cancer (DTC) with lung metastasis using I-131 at Nghe An Oncology Hospital.Methods: A retrospective and prospective descriptive study of 45 DTC patients with lung metastasis diagnosed by whole-body scintigraphy and to evaluate the treatment results with I-131 at the Department of Nuclear Medicine, Nghe An Oncology Hospital from January 2018 to May 2024.Results: DTC patients with lung metastasis had an average age of 47.26 ± 15.75 years old, with a male-to-female ratio of 1/2.5. The pathological type was mainly papillary with a rate of 93.3%. The average thyroglobulin level at the time of stopping the drug was 112.32 ± 154.7 ng/ml. The lesions on whole-body I-131 scan were mainly diffuse hyperactivity with a rate of 77,8%. Patients were treated multiple times with I-131, an average of 3.75 times and had a total cumulative treatment dose of 540 ± 193,73 mCi (150-970). The rate of complete response to I-131 accounted for 17.8%. The rates of incomplete and indeterminate responses were 64.44% and 17.8%, respectively. Age and thyroglobulin stimulation were two valuable factors in predicting the response to I-131 treatment in DTC patients with lung metastases.Conclusion: DTC patients with lung metastasis treated with I-131 at Nghe An Oncology Hospital had a complete response rate of 17.8%, incomplete and undetermined response rates of 64.44% and 17.8%, respectively.

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