Bước đầu nhận xét đặc điểm mô dây thần kinh đồng loài bảo quản lạnh sâu tại Ngân hàng Mô, Bệnh viện Hữu nghị Việt Đức=An initial evaluation of characteristics of cryopreserved allogeneic nerve tissues at Tissue Bank, Viet Duc University Hospital

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Tác giả: Thanh Hòa Đỗ, Đức Hùng Dương, Minh Anh Hoàng, Sỹ Lánh Nguyễn, Thị Điểm Nguyễn, Văn Chỉnh Nguyễn, Thị Hằng Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ Việt Nam - B, 2025

Mô tả vật lý: tr.61

Bộ sưu tập: Metadata

ID: 486864

Thêm vào giỏ

Cryopreservation of allogeneic nerve tissue has been researched and applied in peripheral nerve reconstruction, overcoming the limitations of autografts. This study aims to describe the characteristics of recovery, processing, cryopreservation and distribution of cryopreserved allogeneic nerve tissue at the Tissue Bank, Viet Duc University Hospital. The study uses a descriptive and prospective study method. The results showed that 32 nerve tissues were harvested from 8 brain-death donors. The average age of donors was 34±13 (range from 16 to 50 years old). All donors tested negative for HIV, HBV, and HCV. 32/32 (100%) nerve tissues were ivory-white in colour, intact, without discolouration, tearing, or breakage. Among these, 16 tissues (50%) were saphenous nerve tissues with lengths ranging from 210 to 320 mm and 16 tissues (50%) were tibial nerves with lengths ranging from 100 to 380 mm. All the microbiological culture tests were negative. Three nerve allografts have been transplanted into patients with the normal nerve fibre structures after thawing.Mô dây thần kinh đồng loài bảo quản lạnh sâu đang được nghiên cứu và sử dụng trong ghép tái tạo dây thần kinh bị tổn thương, khắc phục những hạn chế của mô ghép tự thân. Nghiên cứu này nhằm mô tả đặc điểm thu hồi, xử lý, bảo quản, phân phối mô dây thần kinh đồng loài bảo quản lạnh sâu tại Ngân hàng Mô, Bệnh viện Hữu nghị Việt Đức. Nghiên cứu sử dụng phương pháp nghiên cứu mô tả, tiến cứu. Kết quả cho thấy, 32 mô dây thần kinh được thu nhận từ 8 người hiến chết não có độ tuổi trung bình là 34±13 (từ 16 đến 50 tuổi). 100% người hiến mô dây thần kinh đều âm tính với HIV, HBV, HCV. 32/32 (100%) mô dây thần kinh thu nhận có màu sắc trắng ngà và nguyên vẹn, không bị biến sắc hay tưa rách, đứt đoạn. Trong đó, có 16 mô (50%) là dây thần kinh hiển với chiều dài từ 210 đến 320 mm và 16 mô (50%) là thần kinh chày với chiều dài từ 100 đến 380 mm. Tất cả mô dây thần kinh có kết quả nuôi cấy vi sinh âm tính. Ba mô dây thần kinh được ghép cho bệnh nhân có cấu trúc sợi bình thường, chưa thoái hóa sau rã đông.

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