Nghiên cứu một số đặc điểm vùng gen mã hóa protein của chủng Porcine Parvovirus gây bệnh khô thai ở lợn nuôi tại Việt nam=Study on some characteristics of the protein coding gene region of porcine parvovirus causing fetal mummification in pigs in Viet Nam

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Tác giả: Thị Bích Phượng Cao, Hữu Anh Đặng, Thị Mỹ Lệ Huỳnh, Huỳnh Thanh Phương Lê, Thành Trung Nguyễn, Văn Giáp Nguyễn, Thị Ngọc Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học kỹ thuật Thú y, 2024

Mô tả vật lý: tr.22

Bộ sưu tập: Metadata

ID: 486948

Thêm vào giỏ

Bệnh khô thai do porcine parvovirus (PPV) gây ra là một trong những bệnh rối loạn sinh sản ở lợn luôn được người chăn nuôi quan tâm. Mặc dù bệnh này đã xuất hiện ở Việt Nam từ lâu, nhưng cho tới nay có tương đối ít nghiên cứu về bệnh và lưu hành của virus này. Nghiên cứu này được thực hiện nhằm góp phần làm rõ đặc điểm sinh học phân tử cơ bản của chủng virus phân lập PPV.DN.001. Trong 4.752 nucleotide được giải mã, chủng PPV.DN.001 mang đặc điểm của nhóm parvovirus
có khả năng tái bản độc lập với tỷ lệ %GC là 37,2%
không có vùng giàu CpG. Chủng virus mã hóa 4 protein phi cấu trúc và 2 protein cấu trúc với cách sắp xếp mang đặc điểm của virus thuộc giống protoparvovirus. Capsid protein VP1 của chủng PPV.DN.001 mang đầy đủ các vùng chức năng điển hình của PPV. Trong 6 nhóm di truyền của PPV, chủng PPV.DN.001 thuộc nhóm C và sai khác với chủng PPV nhược độc (NADL2) ở 7 vị trí trên capsid protein.Fetal mummification associated with porcine parvovirus (PPV) infection is one of the reproductive disorders in pigs that is always of interest to the pig farmers. Although, this disease has appeared in Viet Nam for a long time, to date there have been relatively few studies on the disease and circulation of this virus. This study was conducted to contribute to clarifying the basic molecular biology of the isolated virus strain PPV.DN.001. Of the 4,752 decoded nucleotides, strain PPV. DN.001 carried characteristics of the parvovirus group, had capability of independent replication with a %GC rate of 37.2%, and did not have a CpG-rich region. The virus encoding 4 non-structural proteins and 2 structural proteins, with typical arrangement carried the characteristics of viruses belonging to the protoparvovirus genus. The VP1 capsid protein of PPV.DN.001 carried all the typical functional domains of PPV. Among 6 genetic groups of PPV, strain PPV.DN.001 belonged to group C and differed with the attenuated PPV strain (NADL2) at 7 positions on the capsid protein.

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