ĐẶC ĐIỂM HÌNH ẢNH CỦA UNG THƯ BIỂU MÔ TẾ BÀO GAN LIÊN QUAN ĐẾN TÌNH TRẠNG KHÁNG TACE=Imaging characteristics of hepatocellular carcinoma associated with transarterial chemoembolization refractoriness

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Tác giả: Đăng Tân Đỗ, Văn Công Nguyễn, Minh Thông Phạm, Hà Châu Trịnh, Đăng Lưu Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Điện quang và Y học hạt nhân Việt Nam, 2024

Mô tả vật lý: tr.67-74

Bộ sưu tập: Báo, Tạp chí

ID: 486960

Thêm vào giỏ

Mục tiêu: So sánh và nhận xét đặc điểm hình ảnh ung thư biểu mô tế bào gan liên quan đến kháng nút mạch hoá chất.Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang, hồi cứu trên 71 bệnh nhân được chẩn đoán ung thư biểu mô tế bào gan và được điều trị nút mạch hoá chất ít nhất 2 lần đầu tiên trong thời gian từ 1/2022 đến 1/2024 tại Trung tâm Điện Quang Bệnh viện Bạch Mai. Bệnh nhân được chia thành hai nhóm kháng TACE và không kháng TACE. Tiến hành so sánh và nhận xét đặc điểm nhân khẩu học, xét nghiệm và đặc điểm hình ảnh giữa hai nhóm để tìm ra yếu tố nguy cơ kháng TACE.Kết quả: Trong 71 bệnh nhân, có 31 bệnh nhân có tình trạng kháng TACE. Đặc điểm về tuổi, giới, yếu tố nguy cơ xơ gan, tình trạng xơ gan theo phân loại Child-Pugh không liên quan đến tình trạng kháng TACE. Phân tích hồi quy logistic đa biến cho thấy sự phân bố khối u hai thuỳ (OR=4,049 CI 95% [1,323
9,267], p = 0,0018), >
1 khối u (OR=5,052 CI 95% [1,052
24,266], p = 0,043) và ngoài tiêu chí up-to-7 (OR=3,555 CI 95% [1,201
7,284], p = 0,026) liên quan đến khả năng kháng TACE, độ dự báo mô hình 74,6%.Kết luận: Đặc điểm hình ảnh phân bố u ở hai thuỳ gan, số lượng u >
1 và ngoài tiêu chí up-to-7 là yếu tố nguy cơ độc lập làm tăng khả năng kháng TACE.Objectives: Comparison and evaluation of imaging characteristics of hepatocellular carcinoma related to refractoriness of transarterial chemoembolization (TACE).Methods: A descriptive cross-sectional, retrospective study was conducted on 71 patients diagnosed with hepatocellular carcinoma and treated with at least two initial chemoembolization procedures from January 2022 to January 2024 at the Radiology Center of Bach Mai Hospital. The patients were divided into two groups: TACE refractoriness and non-TACE refractoriness. A comparison and evaluation of demographic, laboratory, and imaging characteristics between the two groups were conducted to identify risk factors for TACE refractoriness.Results: Out of 71 patients, 31 exhibited TACE refractoriness. Characteristics such as age, gender, risk factors for cirrhosis, and cirrhosis status according to the Child-Pugh classification were not associated with TACE refractoriness. Logistic regression showed that bilobar tumor distribution (OR=4.049, 95% CI [1.323
9.267], p = 0.0018), >
1 tumor (OR=4.052, 95% CI [1.052
5.266], p = 0.043), and beyond the up-to-7 criteria (OR=3.555, 95% CI [1.201
7.284], p = 0.026) were associated with TACE refractoriness, with a model predictive accuracy of 74.6%.Conclusion: Imaging characteristics such as bilobar tumor distribution, more than 1 tumors, and beyond up-to-7 criteria areindependent risk factors that increase the likelihood of TACE refractoriness

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