Clonorchiasis infection is a food-borne parasitic disease that significantly impacts on publichealth. Among the three species of small liver flukes, Clonorchis sinensis (C. sinensis) is the mostprevalent. It is estimated that approximately 35 million individuals worldwide are infected with C.Sinensis, with those affected having a risk of developing cholangiocarcinoma.Methods: This study employed an analytical descriptive study, conducting cross-sectionalsurveys involving 459 individuals aged 18 and older at the study site.Results: The prevalence of infected C. sinensis among humans in Yen Loc commune, Kim Sondistrict, Ninh Binh province, was found to be 19.39%. Of the infected individuals, 92% exhibitedmild infectious intensity, with a mean C. sinensis infection intensity of 241.92 ± 481.45 EPG. Moremale residents (28.44%) were infected with C. sinensis than female (11.20%) residents (p<
0.05).Individuals using fresh manure for farming and animal husbandry had 2.04 times higher odds ofinfection than those who did not utilize fresh manure (95% CI: 1.21-3.43). Furthermore, thoseconsuming raw fish were 7.17 times more likely to be infected compared to those who had nevereaten raw fish (95% CI: 3.60-14.27). The highest prevalence of C. sinensis infection was observedin the group people who consumed raw fish once a week (p <
0.05).Conclusion: The prevalence of C. sinensis infection among humans in Yen Loc commune,Kim Son district, Ninh Binh province, is 19.39%, with the majority of cases classified as mildinfection intensity