Using MRI to determine drug concentration in convection-enhanced Delivery: A Proof-of-Concept study.

• Tác giả: Di Chen, Xiaojie Ding, Chunxia Ji, Ming Qi, Ying Qi, Xinyu Yang, Yu Yao, Yuan Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 658.32259 Personnel management (Human resource management)
• Thông tin xuất bản: Ireland : Neuroscience letters , 2025
• Bộ sưu tập: NCBI
• ID: 487708

Tóm tắt

Convection-enhanced delivery (CED) bypasses the blood-brain barrier and avoids systemic exposure to the drug. However, systemic pharmacokinetic characteristics of a drug cannot be applied when delivered via CED. This study aims to provide a first proof-of-concept framework for noninvasively evaluating pharmacokinetics in CED. We investigated local concentration and the distribution of a gadolinium-based contrast agent in rat brains using magnetic resonance imaging (MRI). Standards of gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) were scanned on a 7.0 T MRI system in rat brain tissue suspension. T