PURPOSE: Heart failure with supra-normal ejection fraction (HFsnEF), defined as HF with left ventricular ejection fraction (LVEF) >
65%, constitutes a novel HF category. However, its clinical characteristics and long-term outcomes remain insufficiently elucidated. We sought to characterize Polish HFsnEF patients and provide their long-term mortality. MATERIAL AND METHODS: Of 1,186 patients enrolled in the single-center Lesser Poland Cracovian Heart Failure (LECRA-HF) registry between years 2009 and 2019, 261 (22%) were classified as HF with LVEF ≥50%. Of them, 40 (15.3%) were classified as HFsnEF, and the remaining 221 (84.7%) as HF with preserved EF (HFpEF). Baseline characteristics, prior cardiovascular treatment, laboratory and echocardiographic measurements have been collected during index hospitalization. The long-term follow-up of all-cause mortality was obtained from the National Death Registry. RESULTS: HFsnEF patients were less frequently hypertensive (75 vs 88.2%, P=0.026) and they were less often treated with mineralocorticoid receptor antagonists (25 vs 46.2%, P=0.013) and loop diuretics (60 vs 76%, P=0.017). The Kaplan-Meier analysis showed that all-cause mortality is higher in HFsnEF than in HFpEF (65 vs 55.2%, P=0.044). The independent predictors of long-term mortality were age and HFsnEF diagnosis (hazard ratio [HR] 1.037, 95% confidence interval [CI] 1.018-1.056
HR 1.665, 95% CI 1.063-2.608, respectively). CONCLUSIONS: Our findings indicate that every 7