The rise of drug-resistant bacteria, including multidrug-resistant (MDR) strains, has exposed the limitations of current antibiotic treatments. Chemodynamic therapy (CDT) has emerged as a promising approach due to its ability to generate reactive oxygen species (ROS) through Fenton or Fenton-like reactions in infection microenvironments (IMEs). However, the short lifespan, limited diffusion range of ·OH, and restricted variety of ROS reduce the effect of CDT. This study developed amine porphyrins (TAPP)-functionalized Fe