TỔNG HỢP HỆ NANO HYDROXYPROPYL-BETACYCLODEXTRIN/ALGINATE LÀM VẬT LIỆU MANG THUỐC=SYNTHESIS OF HYDROXYPROPYL-BETA-CYCLODEXTRIN/ALGINATE NANOPARTICLE AS A NOVEL DRUG DELIVERY SYSTEM

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Tác giả: Tán Văn Hậu, Hiền Nguyễn Cao, Quốc Võ Tấn, Lê Thị Thanh Vân

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học Công nghệ và Thực phẩm (Tên mới: Tạp chí Khoa học Đại học Công Thương), 2017

Mô tả vật lý: tr.89

Bộ sưu tập: Metadata

ID: 487825

Thêm vào giỏ

Bài báo nghiên cứu tổng hợp một hệ nano mới được hình thành từ alginate vàhydroxypropyl-β-cyclodextrin bằng phương pháp gelat ionotropic qua tương tác tĩnh điện giữa Ca2+/alginate và hydroxypropyl-β-cyclodextrin. Đặc tính hình thái và cấu trúc của các hạt nano được khảo sát bằng kính hiển vi điện tử quét (SEM), kính hiển vi điện tử truyền qua (TEM), phổ hồng ngoại (IR). Kích thước hạt nano thu được khá đồng đều trong khoảng 50 - 80 nm. Artesunate (thuốc điều trị sốt rét) được chọn làm mẫu tạo phức với vật liệu, hiệu suất mang thuốc đạt được 88%.Từ khóa: Nanoparticle, hydroxypropyl-β-cyclodextrin, alginate, artesunateThe aim of this work was to study a novel nanoparticle system formed from alginate and hydroxypropyl-β-cyclodextrin by ionotropic gelation method and to evaluate their potential for the association and delivery of drugs. The nanoparticles were prepared by electrostatic interactions between Ca2+/alginategel andhydroxypropyl-β-cyclodextrin. Morphology and structure characterization of nanoparticles was investigated by scanning electron micrographs (SEM), transmission electron microscope (TEM), infrared spectra (IR). The nanoparticle size was about 50 – 80 nm and their structure quite regular and consistent. Atersunate, chosen as a model drug, was incorporated into the nanocarriers with association efficiency of 88 %.Keywords: Nanoparticle, hydroxypropyl-β-cyclodextrin, alginate, atersunat.

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