Integrative spatial analysis reveals tumor heterogeneity and immune colony niche related to clinical outcomes in small cell lung cancer.

• Tác giả: Zhiwei Cao, Haiquan Chen, Chaoqiang Deng, Fanfan Fan, Fangqiu Fu, Jian Gao, Qiming He, Yonghong He, Hong Hu, Tao Hu, Yuan Li, Kun Liu, Xuxia Shen, Jialei Wang, Jin Wang, Jun Wang, Qiming Wang, Yue Wang, Bo Yang, Fei Yang, Mou Zhang, Shiyue Zhang, Yang Zhang, Qiang Zheng, Changbin Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 287.9 Churches related to Methodism
• Thông tin xuất bản: United States : Cancer cell , 2025
• Bộ sưu tập: NCBI
• ID: 487930

Tóm tắt

Recent advances have shed light on the molecular heterogeneity of small cell lung cancer (SCLC), yet the spatial organizations and cellular interactions in tumor immune microenvironment remain to be elucidated. Here, we employ co-detection by indexing (CODEX) and multi-omics profiling to delineate the spatial landscape for 165 SCLC patients, generating 267 high-dimensional images encompassing over 9.3 million cells. Integrating CODEX and genomic data reveals a multi-positive tumor cell neighborhood within ASCL1