Nowadays, plastic pollution is one of the most significant issues affecting the environment, posing a serious threat to marine biodiversity, ecosystem stability, and human health. Millions of tons of plastic waste enter the oceans every year, and the impact of microplastics (MPs) is much more worrying than visible contamination. The presence of these particles puts a strain on ecological dynamics, causing a significant impact on the health of marine organisms and affects humans due to the interconnection existing with the environment and the food chain. This review article examines the different ways in which MPs interact with marine life, the mechanisms that drive this pollution, and the cascading consequences for the health of organisms and ecosystems. It also highlights the critical links between plastic pollution and human health and underlines the urgency of a global and coordinated approach to address this growing crisis. Only through deeper understanding, increased awareness and collective action can we hope to mitigate the significant impacts of plastic pollution and ensure a sustainable future for oceans and our planet.