Nghiên cứu thành phần hóa học và hoạt tính diệt tế bào ung thư của tinh dầu sả cymbopogon citratus thu hái tại tỉnh phú thọ

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Tác giả: Thị Vĩnh Hà Đỗ, Thị Kim Vân Hoàng, Thị Lý Hoàng, Hải Đăng Nguyễn, Minh Quý Nguyễn, Thanh Hải Nguyễn, Thị Hiền Nguyễn, Tiến Đạt Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại: 615 Pharmacology and therapeutics

Thông tin xuất bản: Công nghệ sinh học, 2016

Mô tả vật lý: 683-687

Bộ sưu tập: Metadata

ID: 488122

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Nghiên cứu thành phần hóa học và hoạt tính diệt tế bào ung thư của tinh dầu sả Cymbopogon citratus thu hái tại tỉnh Phú Thọ. Kết quả phân tích thành phần bằng phương pháp sắc ký khí kết nối khối phổ cho thấy hợp chất citral là thành phần chính của các mẫu tinh dầu, chiếm tỷ lệ từ 64,15% đến 76,22% tổng lượng các tinh dầu. Phân tích về tỷ lệ thành phần giữa các mẫu sả củ và sả lá cho thấy hai đồng phần của ocimene có hàm lượng cao hơn ở tinh dầu sả củ so với sả lá. Camphene chỉ phát hiện ở hai mẫu sả của mà không phát hiện được ở các mẫu sả lá thử nghiệm. Myrcene có hàm lượng cao hơn ở tinh dầu sả lá. Các mẫu tinh dầu được thử nghiệm hoạt tính diệt 3 dòng tế bào ung thư gồm: ung thư phổi, ung thư cổ tử cung và ung thư gan. Cả tinh dầu sả Phù Ninh và Thanh Sơn đều cho hiệu quả diệt tế bào ung thư phổi rất mạnh. Đánh chú ý, mẫu tinh dầu sả củ và lá Thanh Sơn còn cho hiệu quả diệt 2 dòng tế bào ung thư cổ tử cung và ung thư gan rất mạnh.The paper investigates the chemical composition and activity of cancer cells of citronella oil Cymbopogon citratus collected in Phu Tho province. The results of component analysis by mass spectrometric gas chromatography show that citral compound is the main component of essential oil samples, accounting for 64.15% to 76.22% of the total amount of essential oils. Analysis of the ratio of components between lemongrass and lemongrass samples showed that the two components of ocimene were higher in lemongrass oil than lemongrass. Camphene only detected in two lemongrass samples that were not detected in the lemongrass samples tested. Myrcene has a higher content in citronella oil. Essential oil samples were tested to kill 3 cancer cell lines including: lung cancer, cervical cancer and liver cancer. Both Phu Ninh citronella and Thanh Son essential oils are very effective at killing lung cancer cells very strongly. Note, Thanh Son citronella and Thanh Son leaf oil samples also effectively kill 2 cell lines of cervical cancer and very strong liver cancer.

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