BACKGROUND AND AIMS: The post operative management of gastric peroral endoscopic myotomy (G-POEM) lacks standardization. This study aimed to evaluate adverse events, readmission rates, and feasibility of same-day discharge (SDD) after G-POEM. METHODS: A multi-center retrospective review of prospectively collected G-POEM data was conducted. The primary outcome was the 15-day readmission rates in SDD and admitted patients. Secondary outcomes included readmission risk factors, clinical success, and adverse events (AEs). RESULTS: We found a 4.1% 15-day readmission rate in 482 patients (95% CI: 3.2%-5.4%). SDD clinical success rates at 6-12 months were 54.1% against 59.7% for the admitted group. The overall AE rate was 4.1%. SDD patients tended to have shorter procedure times, higher frequency of double myotomies, and endoscopic suturing for closure. CONCLUSIONS: G-POEM is safe with low incidence of AEs and 15-day readmission rates. SDD appears safe in uncomplicated cases, suggesting that upper gastrointestinal studies post-G-POEM may be unnecessary.