BACKGROUND: Although headaches are common, only 3-21% are estimated to be secondary, with their causes ranging from non-alarming to life-threatening conditions. OBJECTIVES: Evaluate the associated factors and predictive warning signs of intracranial pathologies in patients presenting with nontraumatic headaches to the emergency document (ED). DESIGN: Retrospective chart review. SETTINGS: Medical center in Jeddah. PATIENTS AND METHODS: Data were collected from all patients who presented to the ED with nontraumatic headaches and underwent brain computed tomography (CT) scans from September 2021 to September 2022. MAIN OUTCOME MEASURES: The associated factors and predictive warning signs of intracranial pathologies. SAMPLE SIZE: 387. RESULTS: Sixty-seven (17.31%) patients had intracranial pathologies. The median (IQR) age of all patients was 49 (23) years and females constituted 61.8%. Patients with intracranial pathologies were significantly more likely to have severe headaches (59.7% vs. 33.7%, CONCLUSIONS: Our findings suggest that these four headache warning signs can help physicians predict intracranial pathologies and subsequently decide which patients should undergo brain imaging in non-traumatic headache cases. LIMITATIONS: Single-center study and retrospective design.