Tác động của môi trường phong phú đến hành vi liên quan khám phá và học tập trên chuột cống được gây mô hình bệnh tự kỷ

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Tác giả: Thu Hồng Đào, Lê Chiến Nguyễn, Hải Anh Trần, Thị Quỳnh Trang Trần

Ngôn ngữ: vie

Ký hiệu phân loại: 612 Human physiology

Thông tin xuất bản: Sinh lý học việt nam, 2017

Mô tả vật lý: 56-64

Bộ sưu tập: Metadata

ID: 488337

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Chủ đề

Gây mô hình bệnh tự kỷ trên chuột cống trắng bằng tiêm phúc mạc axit valproic liều 500 mg/kg thể trong vào ngày 12,5 của thai kỳ.Chuột con sinh ra được chia nhóm ngẫu nhiên, gồm các nhóm được nuôi 28 ngày trong môi trường phong phú và được nuôi trong môi trường chuẩn trong cùng thời gian. Môi trường phong phú làm tăng cường hành vi khám phá trong môi trường mở, có phần làm tăng hoạt động tương tác xã hội cũng như tăng trí nhớ không gian trên chuột cống trước trưởng thành.This study was conducted in order to assess effects of enriched environment (EE) on autism-modelled rat's behaviours. Rats were injected intraperitoneaily with valproic acid (VPA) dosed 500 mg/kg at 12.5 gestational day. Born rat pubs were randomly divided into groups consisting of those raised in enriched environment for 28 days (postnatal day 23 to day 51) and thosed raised in standard environment for the same period. Their behaviors were evaluated via tasks in an open field, in a three-chamber apparatus for social interaction behaviors, and in a water maze. The results showed that (i) the EE enhanced exploratory activities of rats in the open field
(ii) partially improved the social interaction behaviors as well as (iii) spatial memory in young rats. Thus, the enriched environment has ameliorative effects on exploratory and learning-related behaviours in autism-modelled rats.

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