Owning to seriously impaired capacity of bone regeneration, the repair of osteoporotic bone defect remains a major clinical challenge in orthopedics. For titanium mesh scaffolds of skull repair, to construct bio-coatings targeting the pathological environment of osteoporosis is significant. Here, tannic acid (TA)/casein phosphopeptide (CPP) based layer-by-layer (LBL) self-assembled coating that loaded with anti-osteoporotic alendronate sodium (AS) and bioactive Mg