Tanning agents are chemical substances that cause structural changes in collagen. Zirconium tanning agent is a promising alternative to chromium tanning agent, but the problem of uneven tanning due to its rapid binding to collagen limits its practical application in leather manufacturing. In this study, a combined tanning strategy based on layered double hydroxides (LDHs) and zirconium sulfate was proposed, aiming to promote the uniform distribution of conventional zirconium tanning agents in collagen fibers and to improve the physicochemical properties of tanned leather through the memory effect of LDHs. The nanostructure of LDHs was modulated by calcination treatment to increase their specific surface area, Al