Enhanced dual-drug loaded κ-carrageenan/agar hydrogel films for wound dressing: Optimizing swelling and drug release.

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Tác giả: Shirin Arayesh, Ali Ayati, Somayeh Khazaei Far, Saeedeh Movaghar Khoshkho, Mahdi Niknam Shahrak, Bahareh Tanhaei

Ngôn ngữ: eng

Ký hiệu phân loại: 616.8918 Diseases of nervous system and mental disorders

Thông tin xuất bản: Netherlands : International journal of biological macromolecules , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 488461

This study presents the development of antibacterial hydrogel films based on natural biopolymers, κ-carrageenan and agar, crosslinked with KCl for wound healing applications. The hydrogels were loaded with tetracycline (TC) and clove extract to enhance antimicrobial properties, while the addition of Triton X-100 (TX-100) improved drug solubility and bioavailability, leading to higher drug release rates. Swelling behavior was evaluated in distilled water (DW), simulated wound fluid (SWF), and phosphate-buffered saline (PBS), with maximum swelling observed at 399 %, 222 %, and 124 %, respectively. Swelling kinetics followed pseudo-second-order and Korsmeyer-Peppas models, suggesting a Fickian diffusion mechanism. Drug release profiles were influenced by medium type and clove concentration, with the highest release observed in SWF at a clove concentration of 8 mg L
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