PURPOSE: To compare rates of post-operative complications, healthcare utilization, opioid prescribing patterns, and secondary knee surgery in patients with versus without a preexisting anxiety or depressive disorder (ADD) undergoing isolated primary arthroscopic partial meniscectomy (APM). METHODS: The TriNetX database was queried from inception to compare patients over 18-years-old who underwent isolated primary APM with versus without a pre-existing ADD. Patients were matched in a 1:1 ratio based on demographic factors and comorbidities, including diabetes and hypertension. The following outcomes were collected: 1) post-operative complications and healthcare utilization within ninety days, 2) proportion of patients prescribed an opioid within one year, and 3) subsequent knee surgery within two years, specifically ipsilateral or contralateral meniscus surgery or total knee arthroplasty. Two subgroup analyses were conducted. Opioid naive patients with and without an ADD were compared based on the proportion of patients prescribed an opioid within one year of APM. Rates of revision meniscus surgery on the ipsilateral knee were also compared within two years of APM. RESULTS: Within 90 days, patients with a pre-existing ADD (n=26,507), compared to those without (n=26,507), had higher rates of healthcare utilization, including readmission (p<
0.001), and medical complications, like cerebrovascular accident (p=0.002). A greater proportion of patients with an ADD were prescribed opioids at all chosen time points within one year of APM. Similarly, a greater proportion of opioid naive patients with an ADD were prescribed opioids within six months (p<
0.001) and one year (p<
0.001). Patients with an ADD also had higher rates of total knee arthroplasty (p=0.001) and ipsilateral revision meniscus surgery (left knee: p=0.020
right knee: p=0.019) within two years. CONCLUSION: Patients with an anxiety or depressive disorder have higher rates of healthcare utilization, medical complications, opioid prescriptions, and subsequent knee surgery after isolated primary arthroscopic partial meniscectomy. LEVEL OF EVIDENCE: III, retrospective cohort study.