Targeting YTHDF2 impacts the epitranscriptome and overcomes tumor therapy resistance.

• Tác giả: Qiwei Ge, Li Han, Zhicong Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 354.59 *Commodity programs
• Thông tin xuất bản: England : Trends in cell biology , 2025
• Bộ sưu tập: NCBI
• ID: 489385

Tóm tắt

Dysregulation of RNA modifiers is common across cancer types and has essential roles in tumor therapy resistance. Chen and colleagues reported that YTHDF2 played dual roles in B cell malignancies by enhancing cell proliferation and promoting immune evasion. Targeting YTHDF2 with inhibitors offers an approach to tumor treatment by regulating the epitranscriptome.