Nghiên cứu giá trị chỉ số nlr, plr trong dự báo đáp ứng điều trị ung thư phổi không tế bào nhỏ với phác đồ hóa chất có platinum

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Huỳnh Đức Lê, Thị Minh Châu Nghiêm, Đức Hạnh Nguyễn, Thanh Xuân Nguyễn, Ngọc Điệp Phạm

Ngôn ngữ: vie

Ký hiệu phân loại: 616.994 +Cancers

Thông tin xuất bản: Tạp chí y học việt nam (tổng hội y học việt nam), 2022

Mô tả vật lý: 296-301

Bộ sưu tập: Metadata

ID: 489405

Thêm vào giỏ Liên kết toàn văn

Tóm tắt
Chủ đề

Determining the optimal threshold value of pretreatment NLR and PLR index in predicting treatment response in stage IV NSCLC patients who received platinum-based chemotherapy and association with clinical and subclinical characteristics. Subjects and methods(:) A retrospective and prospective descriptive study on 53 stage IV NSCLC patients who received platinum-based chemotherapy regimens at the Oncology Center - Military Hospital 103 and the Oncology Department - National Lung Hospital from January 2019 to August 2022. Results(:)( )the threshold value for predicting the chemical treatment response of pretreatment NLR was 3.75, and that pretreatment PLR was 194. Patients with high NLR, PLR had significantly higher PS and worse responses to the treatment than those with low NLR, PLR (p và lt
0.01). The proportion of men and right lung tumors in the PLR group ≥ 194 was significantly higher than in the PLR group và lt
194 respectively with p = 0.019
p= 0.018. Conclusion(:) Pretreatment NLR and PLR indexes can predict treatment outcomes in stage IV NSCLC patients who received platinum-based chemotherapy regimens.Xác định ngưỡng giá trị tối ưu của chỉ số NLR, PLR trước điều trị trong dự báo đáp ứng điều trị ung thư phổi không tế bào nhỏ giai đoạn IV với phác đồ hóa chất có Platinum và mối liên quan với đặc điểm lâm sàng, cận lâm sang. Đối tượng và phương pháp(:) nghiên cứu mô tả cắt ngang hồi cứu kết hợp tiến cứu trên 53 bệnh nhân ung thư phổi không tế bào nhỏ giai đoạn IV được điều trị hóa chất bước 1 với phác đồ có Platinum tại Trung tâm Ung bướu - Bệnh viện Quân y 103 và Khoa Ung bướu - Bệnh viện Phổi Trung ương từ tháng 1/2019 - tháng 8/2022. Kết quả(:) ngưỡng giá trị để dự báo đáp ứng điều trị hóa chất của NLR trước điều trị là 3,75, của PLR trước điều trị là 194. Bệnh nhân có NLR, PLR cao có chỉ số toàn trạng cao hơn và đáp ứng điều trị hóa chất kém hơn so với NLR, PLR thấp (p và lt
0,01). Tỉ lệ nam giới, u( )phổi phải ở nhóm PLR ≥ 194 cao hơn có ý nghĩa so với nhóm PLR và lt
194 lần lượt với p = 0,019
p= 0,018. Kết luận(:) chỉ số NLR, PLR trước điều trị có khả năng dự báo đáp ứng điều trị bệnh nhân ung thư phổi không tế bào nhỏ giai đoạn IV với phác đồ có chứa Platinum.

Tạo bộ sưu tập với mã QR