Khảo sát nhiễm hpv-16/-18 và mối liên quan với một số đặc điểm lâm sàng ở bệnh nhân ung thư phổi

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Tác giả: Thị Ngọc Dung Đặng, Phương Giang Đào, Hoàn Lê, Thị Thanh Xuân Lê, Xuân Hoàn Nghiêm, Thị Linh Hoa Nguyễn, Quốc Hoàn Phan, Xuân Hinh Quách, Khánh Chi Trần

Ngôn ngữ: vie

Ký hiệu phân loại: 616.994 +Cancers

Thông tin xuất bản: Tạp chí y học việt nam (tổng hội y học việt nam), 2022

Mô tả vật lý: 25-30

Bộ sưu tập: Metadata

ID: 489408

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Determine the prevalence of HPV-16/-18 infection on lung biopsy tissue samples in lung cancer patients and analyze clinical and subclinical characteristics in HPV-16/-18-positive LC patients. Subjects and methods(:) Developing a multiplex realtime PCR method to detect HPV-16/-18 on clinical specimens. This study was conducted on 273 lung cancer patients treated at the 108 Military Central Hospital from 7/2021-9/2022. HPV-16/-18 DNA in lung cancer biopsy tissue samples was determined by our inhouse developed/optimized multiplex realtime PCR technique. Results(:) The rate of HPV-16/-18 infection in lung cancer was 5.1%, of which HPV-16 accounted for 57.1% and HPV-18 accounted for 42.9%. The rate of HPV-16/-18 infection in lung cancer patients was higher in women than in men. HPV-16/-18 infection in female patients positive for EGFR mutations had significantlyhigher than in male patients negative for EGFR mutations (pvà lt
0.05). Conclusions(:) The rate of HPV-16/-18 infection in lung cancer biopsy tissues is 5.1%. Female patients had a( )higher rate of HPV infection than men. Female patients positive for EGFR mutations are possibly prone to HPV infection than men negative for EGFR mutations.Xác định tỷ lệ nhiễm HPV-16/-18 trên mẫu mô sinh thiết phổi ở bệnh nhân ung thư phổi (UTP) và phân tích một số đặc điểm lâm sàng và cận lâm sàng ở bệnh nhân UTP dương tính với HPV-16/-18. Đối tượng và phương pháp(:) Sử dụng phương pháp Multiplex Realtime PCR nhằm phát hiện HPV-16/-18 trên mẫu bệnh phẩm lâm sàng. Nghiên cứu hồi cứu trên 273 bệnh nhân UTP được điều trị tại Bệnh viện Trung ương Quân đội 108 từ 7/2021-9/2022. DNA HPV-16/-18 trong mẫu mô sinh thiết UTP được xác định bằng kỹ thuật Realtime PCR. Kết quả(:) Tỷ lệ nhiễm HPV-16/-18 trong UTP là 5.1% trong đó HPV-16 chiếm 57.1% và HPV-18 chiếm 42.9%. Tỷ lệ nhiễm HPV-16/-18 trên bệnh nhân UTP ở nữ cao hơn nam, ở bệnh nhân nữ có đột biến EGFR (+) cao hơn ở bệnh nhân nam có đột biến EGFR âm tính (pvà lt
0.05). Kết luận(:) Tỷ lệ nhiễm HPV-16/-18 trên mẫu mô sinh thiết UTP là 5.1%, trong các bệnh nhân UTP phụ nữ có nguy cơ nhiễm HPV cao hơn nam giới, quan sát thấy phụ nữ có đột biến EGFR (+) có thể có nguy cơ nhiễm HPV cao hơn nam giới không có đột biến EGFR.

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