Ectodermal dysplasia, a disorder inherited through an X-linked recessive trait, is characterized by abnormalities in two or more structures that originate in the ectoderm. Dental manifestations include missing or malformed teeth. This clinical report details 16 years of interdisciplinary management, starting at age 7 and concluding after skeletal maturation, for a patient with ectodermal dysplasia. Initial treatment included an implant-assisted mandibular overdenture and a maxillary partial prosthesis to improve mastication, speech, and esthetics and to preserve alveolar bone. The prostheses were periodically adjusted to account for facial growth, and additional implants were placed after the completion of growth. The definitive rehabilitation involved maxillary and mandibular implant-supported fixed prostheses with a milled titanium thimble bar and single monolithic zirconia crowns.