Nghiên cứu tác dụng cầm máu và độ an toàn của công thức bào chế viên nang cao bẹ móc trên thực nghiệm

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Thị Vui Đào, Hồng Linh Trần

Ngôn ngữ: vie

Ký hiệu phân loại: 615 Pharmacology and therapeutics

Thông tin xuất bản: Tạp chí nghiên cứu dược và thông tin thuốc, trường đai học dược hà nội, 2023

Mô tả vật lý:

Bộ sưu tập: Metadata

ID: 489541

Thêm vào giỏ Liên kết toàn văn

Tóm tắt
Chủ đề

Đánh giá tác dụng cầm máu và độ an toàn của viên nang bẹ cây Móc trên chuột thí nghiệm. Kết quả thu được cho thấy(:) Viên nang bẹ móc ở cả 2 mức liều thử 360 mg/kg và 540 mg/kg chuột cống trắng (tính theo cao khô bẹ móc) có tác dụng làm giảm thời gian chảy máu trên mô hình gây chảy máu do cắt đuôi chuột, nhưng không ảnh hưởng đến thời gian đông máu ở liều 180 mg/kg và 270 mg/ kg thỏ. Mẫu thử viên nang bẹ móc không thể hiện độc tính cấp trên chuột nhắt trắng ở liều 20 g/kg. Khi dùng liều lặp lại 28 ngày trên chuột cống trắng, chế phẩm viên nang bẹ móc với các mức liều thử 350 mg/ kg và 1050 mg/kg/ngày không ảnh hưởng đến các thông số tình trạng chung, cân nặng, chức năng tạo máu, chức năng thận. Về chức năng gan, có 2 thông số AST và ALT tăng nhẹ ở các lô chuột giống cái dùng liều 1050 mg/ kg(:) ALT tăng 24% (p = 0,045) và AST tăng 27% (p = 0,0498) so với lô chứng cùng giống. Sau 14 ngày ngừng dùng mẫu thử, hai thông số này của chuột đều phục hồi về mức bình thường.The purpose of this research was to evaluate the hemostatic effect and safety of the formulation from Caryota mitis collar extract in animal. The pharmacological actions and the toxicological effect of the formulation were investigated using the subaqueous tail bleeding time in rats
blood-clotting time in rabbits
oral acute toxicity in mice and 28 days oral repeated doses in rats. On oral administration with the dose of 360 mg/kg and 540 mg/kg in rats, the formulation produced significant decrease in bleeding time with the reduction rate 42.7% and 39,4% respectively. The formulation did not show any significant changes in clotting time in rabbits with the dose of 180 mg/kg and 270 mg/kg. In the acute oral toxicity test, a maximal dose of 20 g/kg was not lethal to the mice and did not cause any manifestations of toxicity. Repeated doses (350 mg/kg and 1050 mg/kg/day) for 28 days in rats did not appear to affect the general condition parameters, body weight, hematopoietic function, kidney function. The raises of AST and ALT in higher dose (1050 mg/kg) female rats had recovered to normal levels after 14 days of discontinuing. The Caryota mitis collar extract capsules have hemostatic activity without significant change in blood coagulation. Acute and sub-chronic toxicological properties provide safety profile for the development of the hemostatic fomulation.

Tạo bộ sưu tập với mã QR