Khảo sát tình hình sử dụng kháng sinh trong điều trị đợt cấp copd tại bệnh viện 74 trung ương

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Tác giả: Sơn Nhật Bùi, Thị Luyến Lê, Thành Trung Trần, Xuân Bách Trần

Ngôn ngữ: vie

Ký hiệu phân loại: 612 Human physiology

Thông tin xuất bản: Tạp chí khoa học y dược - đại học quốc gia hà nội, 2022

Mô tả vật lý: 56-64

Bộ sưu tập: Metadata

ID: 489619

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Acute exacerbation of COPD (AECOPD) represents a pivotal point in the progression of COPD, which is a major cause of physician visits, hospitalization, and death in COPD patients. Bacterial respiratory infections have long been considered the main cause of exacerbations. This study was conducted with the aim of surveying the antibiotic usage characteristics in AECOPD of hospitalized patients at National Hospital 74. Data were collected from 265 patients hospitalized from January 1st , 2021 to March 31st , 2021. Most of the patients in the study were male (82.3%) and had comorbidities (74.7%). The most isolated bacteria were Haemophilus influenzae, Moraxella catarrhalis, and Pseudomonas aeruginosa. The majority of patients did not change their antibiotic regimen during treatment (61.5%). Alternative regimens in patients having regimen changes tended to be more focused on Pseudomonas aeruginosa than the first regimens. In the antibiotic-containing regimens tested antibiograms of 38 patients with isolated bacteria, most of the regimens had at least 1 antibiotic sensitive to the isolated bacteria (38.5%). The results of this study provide reliable information for making recommendations to contribute to improving the effectiveness of antibiotic usage in the AECOPD treatment at National Hospital 74, reducing the medical burden for patients and society.Đợt cấp của COPD (AECOPD) thể hiện một thời điểm quan trọng trong sự tiến triển của COPD, là nguyên nhân chính của việc thăm khám bác sĩ, nhập viện và tử vong ở bệnh nhân COPD. Nhiễm trùng đường hô hấp do vi khuẩn từ lâu đã được coi là nguyên nhân chính gây ra đợt cấp. Nghiên cứu này được thực hiện với mục tiêu khảo sát tình hình sử dụng kháng sinh ở bệnh nhân nhập viện điều trị đợt cấp COPD tại Bệnh viện 74 Trung ương. Dữ liệu thu thập được từ 265 bệnh nhân nhập viện trong giai đoạn 01/01/2021 - 31/03/2021. Đa số bệnh nhân trong mẫu nghiên cứu là nam (82,3%) và có bệnh mắc kèm (74,7%). Các vi khuẩn phân lập được nhiều nhất là Haemophilus influenzae, Moraxella catarrhalis, Pseudomonas aeruginosa. Phần lớn bệnh nhân không thay đổi phác đồ kháng sinh trong quá trình điều trị (61,5%). Các phác đồ thay thế ở những bệnh nhân có thay đổi phác đồ có xu hướng tập trung đến Pseudomonas aeruginosa hơn so với phác đồ ban đầu. Trong các phác đồ chứa kháng sinh được thử kháng sinh đồ của 38 bệnh nhân phân lập được vi khuẩn, phác đồ có ít nhất 1 kháng sinh nhạy cảm với vi khuẩn phân lập được chiếm đa số (38,5%). Kết quả của nghiên cứu này cung cấp một căn cứ tin cậy để đưa ra khuyến cáo góp phần nâng cao hiệu quả sử dụng kháng sinh trong điều trị đợt cấp COPD tại Bệnh viện 74 Trung ương, giảm gánh nặng y tế cho bệnh nhân và toàn xã hội.

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