Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer.

• Tác giả: Charles Bayly-Jones, Srikanth Budnar, Anderly C Chüeh, Kimberley C Clark, Thomas R Cotton, David R Croucher, Roger J Daly, Andrew M Ellisdon, Changyuan Hu, Sharissa L Latham, Terry C C Lim Kam Sian, Xiuquan Ma, Bao V Nguyen, Elizabeth V Nguyen, Lan K Nguyen, Sung-Young Shin, Margaret M Stratton, Xue Yang, Tianyue Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 636.0838 Animal husbandry
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 489647

Tóm tắt

The PEAK family of pseudokinases, comprising PEAK1-3, play oncogenic roles in several poor prognosis human cancers, including triple negative breast cancer (TNBC). However, therapeutic targeting of pseudokinases is challenging due to their lack of catalytic activity. To address this, we screen for PEAK1 effectors and identify calcium/calmodulin-dependent protein kinase 2 (CAMK2)D and CAMK2G. PEAK1 promotes CAMK2 activation in TNBC cells via PLCγ1/Ca