Ảnh hưởng nồng độ bạc nano lên tính kháng khuẩn và tương thích sinh học của gel Poly vinyl alcohol/Chitosan/AgNPs

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Tác giả: Ngọc Thảo Nhi Đặng, Thị Hiệp Nguyễn, Thị Thanh Ngọc Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại: 620.5 Nanotechnology

Thông tin xuất bản: Tạp chí Công Thương, 2018

Mô tả vật lý: 508-512

Bộ sưu tập: Metadata

ID: 490292

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Chủ đề

Mục tiêu của nghiên cứu này là khảo sát ảnh hưởng của nồng độ Ag lên tính kháng khuẩn và tương thích sinh học của hai hệ gel Poly vinyl alcohol/nano Ag (PA) và Poly vinyl alcohol/Chitosan/nano Ag (PCA) bằng 2 phương pháp tương ứng là khuếch tán trên đĩa thạch với 2 hai dòng vi khuẩn gram âm (Pseudomonas aeruginosa) và gram dương (Staphyloccocus aureus) và bằng phương pháp MTT trên dòng nguyên bào sợi chuột. Kết quả chỉ ra khả năng kháng khuẩn của hệ gel PA tăng khi tăng dần nồng độ Ag từ 7.5 ppm đến 60 ppm và nồng độ Ag tăng hỗ trợ tế bào tăng sinh. Riêng hệ gel PCA lại cho thấy được hiệu quả kháng khuẩn tăng đáng kể khi kết hợp thêm Cs và giảm nồng độ thành phần nano Ag. Tuy nhiên, thành phần Cs lại làm giảm khả năng tương thích sinh học của hệ gel PCA do có sử dụng axit acetic để hòa tan Cs.The objective of this study was to investigate the effect of Ag concentration on antibacterial and biocompatibility of two systems of Poly vinyl alcohol / nano Ag (PA) and Poly vinyl alcohol / Chitosan / nano Ag (PCA) by The two methods respectively diffuse on agar plates with two strains of gram-negative bacteria (Pseudomonas aeruginosa) and gram-positive (Staphyloccocus aureus) and by MTT method on mouse fibroblasts. The results showed that the antibacterial ability of PA gel system increases with increasing Ag concentration from 7.5 ppm to 60 ppm and increased Ag concentration supports cell proliferation. Particularly, PCA gel system showed a significant increase in antibacterial effect when combined with Cs and reduced concentration of nano-Ag components. However, the Cs component reduces the biocompatibility of the PCA gel system by using acetic acid to dissolve Cs.

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