Tác dụng phục hồi tổn thương gan của cao chiết từ cây mũi mác trên thực nghiệm

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Tác giả: Thị Bích Thu Nguyễn, Trọng Thông Nguyễn, Thị Anh Thư Nông, Thị Vân Anh Phạm

Ngôn ngữ: vie

Ký hiệu phân loại: 571.952 Physiology and related subjects

Thông tin xuất bản: Khoa học và Công nghệ (Đại học Thái Nguyên), 2018

Mô tả vật lý: 203-207

Bộ sưu tập: Metadata

ID: 491347

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Chủ đề

Đánh giá tác dụng làm tăng phục hồi tổn thương gan của cao toàn phần và phân đoạn ethylacetat chiết xuất từ cây mũi mác trên mô hình gây viêm gan bằng paracetamol ở chuột nhắt trắng. Kết quả cho thấy mũi mác phân đoạn ethyl acetat liều 9,6g/kg và 28,8g/kg và mũi mác cao toàn phần liều 9,6g/kg và 28,8g/kg có tác dụng tăng phục hồi tổn thương gan cấp gây ra bởi paracetamol trên chuột nhắt trắng.Effect of Mui mac was studied on acute liver injury induced by single dose of paracetamol 400 mg/kg, po, in mice. Activity was monitored by estimating the serum transaminases (ALT and AST), MDA content in liver homogenates, and by histopathological changes in the livers of experimental mice. The results showed that segment ethylacetate and total extraction of Mui mac with dose of 9.6 grs/kg per day and 28.8 grs/kg per day reduced in the level of serum ALT, AST and ameliorated paracetamol-induced histopathological changes in the livers of experimental mice. The results suggest that Mui mac has acceleratedofliver injury recover against paracetamol intoxication in mice.

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