A novel device consisting of amplifiers, an analogue-digital converter, offset correction units, and a microcontroller with Bluetooth wireless functionality was fabricated. Electroretinography (ERG) recordings were captured in dark-adapted and light-adapted full-field flash stimulations in an anaesthetised animal model using the novel wireless system. Recordings were repeated using a standard ERG recording setup of the Espion E3 system for comparison. The electroretinogram signal a-wave and b-wave amplitudes, peak times, signal offset, potential drift, and power line noise were compared between the recording setups. Signals from the novel system were found to have similar waveforms to those recorded from the standard ERG setup. There were no significant differences in the a-wave amplitudes (P >
0.43), a-wave peak times (P >
0.61) and b-wave peak times (P >
0.55). The offset potential drift when using the novel system was significantly smaller than the reference system (P <
0.02). The novel system also showed stronger resilience against powerline noise interference, as evidenced by a statistically significant performance increase during recordings with substantial noise interference (P <
0.01). The on-source signal processing and wireless transmission can improve the quality of recorded ERG signals. Our study demonstrates a proof of concept for performing wireless ERG recordings, which enhance the performance by reducing noise and potential drift in the recorded signals.