Hiệu quả hạ glucose huyết, điều hòa lipid huyết và chống huyết khối trên chuột bệnh đái tháo đường của lá xoài (Mangifera indica L.)

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Tác giả: Thị Xuân Trang Đái, Thị Ái Lan Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại: 634.44 Anacardiaceous fruits

Thông tin xuất bản: Sinh học, 2018

Mô tả vật lý: 168-176

Bộ sưu tập: Metadata

ID: 492072

Thêm vào giỏ

Inthis study, the antihyperglycemic and antihyperlipidemic effects of Mangifera indica L. (MIL) young leaves extract were investigated using diabetic mice models. Male Mus muscu/us L. mice were intratoripeneally injected by Alloxan monohydrate (AM) to induce diabetes and were observed for 28 days. The blood glucose, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL_C), low-density lipoprotein cholesterol (LDL_C) and atherogenic index were evaluated. The acute toxicity of MIL was determined at the dose of 1000, 2500, 5000 mg/kg body weight of normal mice. Diabetic mice were orally administrated with extract of MIL (150, 300, 450 mg/kg body weight/ twice a day). The results showed that the MIL significantly decreased the plasma glucose, TC, TG, LDL_C levels and atherogenic index and greatly elevated the HDL_C level in diabetic mice (p <
0.05). The methanol extract of young leaves showed the antidiabetic and antihyperlipidemic potential. Altogether, Mangiferine indica L. leaves could be considering as a promising therapy in preventing the complications of diabetes.Khảo sát hiệu quả hạ glucose huyết, điều hòa lipid huyết và chống huyết khối trên chuột bệnh đái tháo đường của lá xoài (Mangifera indica L.). Kết quả cho thấy dịch chiết không gây độc tính cấp trên chuột nhắt trắng. Sau 28 ngày khảo sát, dịch chiết lá xoài non có khả năng hạ glucose huyết ở chuột bệnh đáo tháo đường. Dịch chiết có khả năng giảm cholesterol tổng, triglyceride, LDL-C, chỉ số động mạch và tăng HDL-C ở nhóm chuột bệnh đái tháo đường.

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