Một số đặc điểm bệnh lý chủ yếu của chó được gây nhiễm thực nghiệm bằng chủng virus CDV-HV

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Tác giả: Hữu Nam Nguyễn, Thị Huyền Nguyễn, Vũ Sơn Nguyễn, Ngọc Thạch Phạm

Ngôn ngữ: vie

Ký hiệu phân loại: 591.67 Specific topics in natural history of animals

Thông tin xuất bản: Khoa học Kỹ thuật Thú y, 2018

Mô tả vật lý: 27-35

Bộ sưu tập: Metadata

ID: 492243

Thêm vào giỏ

Bệnh Ca-rê (Canine Distemper) là bệnh truyền nhiễm cấp tính do virus gây ra ở chó. Kết quả gây nhiễm 5 con chó vàng, Việt Nam, 2 tháng tuổi bằng phương pháp khí dung qua niêm mạc mũi, hầu họng với chủng virus Ca-rê CDV-HV, liều 106TCID50/ ml/ con cho thấy: Triệu chứng lâm sàng chủ yếu của chó được gây nhiễm chủng virus Ca-rê (CDV-HV) là sốt, ho, chảy nước mũi, khó thở, giảm ăn, nôn mửa, tiêu chảy có máu và xuất hiện các nốt sần đỏ trên vùng da bụng. Chó mắc bệnh có số lượng bạch cầu, số lượng hồng cầu, hàm lượng Hb, tỷ khối huyết cầu đều giảm so với chó đối chứng. Bệnh tích đại thể của chó được gây nhiễm là viêm phổi xuất huyết, viêm ruột xuất huyết, tích nước ở các xoang, hạch lympho sưng và não sung huyết. Bệnh tích vi thể chủ yếu là sung huyết, xuất huyết và thâm nhiễm tế bào viêm ở các cơ quan: phổi, ruột, hạch lympho, thận, gan. Tế bào nhu mô của gan, thận, hạch lympho, tế bào biểu mô ruột thoái hóa, hoại tử. Bệnh tích vi thể ở não là sung huyết mạch quản và thâm nhiễm tế bào viêm xung quanh mạch quản não, xuất hiện thể vùi trong nhân tế bào thần kinh (neuron). Tế bào biểu mô phế quản, ruột, tế bào hạch lympho là nơi tập trung nhiều virus Ca-rê được phát hiện bằng phương pháp hóa mô miễn dịch.Canine Distemper is an acute viral infectious disease in dogs. This study was conducted to characterize the pathological features of the infected dog by experimental infection. Five Viet Namese, yellow dogs at 2-months-old were infected with the CDV-HV strain via nasal and oropharyngeal mucosa with a dose of 106 TCID50/ml/dog. The studied result showed that the main clinical symptoms of the infected dogs were fever, cough, nasal discharge, dyspnea, decreased appetite, vomiting, bloody diarrhea and nodules on the skin. All the values of white and red blood cell counts, Hb content as well as blood cell density were decreased in comparison to those of the control dogs. The gross lesions of the infected dogs exhibited hemorrhagic pneumonia, hemorrhagic enteritis, fluid storage in the cavities, swollen lymph nodes and brain congestion. Major histological lesions included congestion, haemorrhage and existence of inflammatory cells in the organs (lung, intestine, lymph node, kidney, liver). The liver, kidneys, lymph nodes, intestinal epithelial cells showed the degeneration and necrosis. The brain tissues were congested and infiltration of inflammatory cells surrounding the cerebral vascular system, viral inclusions occured in the nerve cells. The bronchial epithelial cells, intestines, lymph nodes exhibited the aggression of virus particles.

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