Khảo sát thành phần flavonoid trong cây cỏ cứt lợn (Ageratum conyzoides L. Asteraceae)

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Tác giả: Thị Kim Liên Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại: 582.13 $Plants noted for their flowers

Thông tin xuất bản: Tạp chí khoa học và công nghệ - Đại học Nguyễn Tất Thành, 2018

Mô tả vật lý: 60-65

Bộ sưu tập: Metadata

ID: 492377

Thêm vào giỏ

Cỏ cứt lợn (Ageratum conyzoides (L.) Asteraceae), là một dược liệu được dân gian sử dụng phổ biến để chữa bệnh viêm xoang. Trong số các thành phần hóa học đã được công bố của Cỏ cứt lợn, nhóm hoạt chất flavonoid là nhóm thể hiện hoạt tính kháng viêm đáng kể. Đề tài được tiến hành nhằm mục đích cung cấp cơ sở hóa thực vật cho việc sử dụng Cỏ cứt lợn trong điều trị viêm xoang mũi. Bột dược liệu được ngấm kiệt với ethanol 96%. Dịch chiết ethanol toàn phần được phân chia thành ba phân đoạn bằng cách lắc phân bố với ether dầu hỏa 30 - 60oC (PE), dicloromethan (DCM) và ethyl aceat (EA). Các phân đoạn được định tính bằng thuốc thử flavonoid và phân tích bằng sắc ký cột để tìm flavonoid tinh khiết. Các chất được nhận dạng sơ bộ trên TLC và phân tích bằng phổ UV-Vis và MS. Kết quả cho thấy flavonoid tồn tại trong cả ba phân đoạn, trong đó phân đoạn PE và DCM chứa các flavonoid đã methoxy hóa
phân lập được bốn flavonoid AC1, AC2, AC7 và AC8, sơ bộ xác định được AC7 là một trimethoxyflavon và AC8 là một tetramethoxyflavon..Goat weed (Ageratum conyzoides (L.) Asteraceae), a popular folk medicine used to treat sinusitis. Among the published chemical constituents of the goat weed, the flavonoid group is a group that exhibits significant anti-inflammatory activity. The study was conducted to provide chemical evidences for the use of goat weed in the treatment of sinusitis. Dry plant powder was extracted with ethanol 96%. The total ethanol extract was divided into three fractions by shaking with petroleum ether 30-60 oC (PE), dichloromethane (DCM) and ethyl aceat (EA). Segments were characterized by flavonoid reagents and analyzed by column chromatography for pure flavonoids. The substances were preliminarily identified on TLC and analyzed by UV-Vis and MS spectra. Results showed that flavonoids exist in all three segments, where PE and DCM segments contain methoxyflavones
The four flavonoids AC1, AC2, AC7 and AC8 were isolated, preliminarily determining that AC7 is a trimethoxyflavone and AC8 is a tetramethoxyflavone.

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