Evaluation of aortic arch calcification to predict prognosis after transcatheter aortic valve replacement.

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Tác giả: Ailifeire Aihemaiti, Jun Chen, Hanyi Dai, Jiaqi Fan, Yuchao Guo, Yuxin He, Qiong Liu, Xianbao Liu, Wenjing Sheng, Jian'an Wang, Yanxia Wei, Shuangshuang Yang, Abuduwufuer Yidilisi, Rongrong Zheng, Dao Zhou, Qifeng Zhu

Ngôn ngữ: eng

Ký hiệu phân loại: 371.144 Evaluation of teachers

Thông tin xuất bản: England : Scientific reports , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 493148

 Few centers routinely report aortic arch calcification (AAC) due to the lack of an easy and effective evaluation method. The association between AAC and the clinical prognosis of patients who undergo transcatheter aortic valve replacement (TAVR) is unclear. We aimed to develop a rapid method to evaluate AAC in patients who underwent TAVR and to further assess their prognosis. We enrolled 464 consecutive patients with aortic stenosis who underwent TAVR. Patients with severe (11.2%), moderate (18.5%), mild (58.2%), and no (12.1%) AAC had an estimated 3-year all-cause mortality incidence of 39.6%, 20.8%, 13.4%, and 6.7% (log rank p <
  0.001), respectively. Patients with severe AAC had a significantly higher incidence of both cardiovascular (log rank p = 0.002) and non-cardiovascular mortality (log rank p = 0.009), whereas patients with moderate AAC had a higher incidence of only non-cardiovascular mortality (p = 0.003) compared with patients with no/mild AAC. Moderate/severe AAC was an independent predictor of 3-year all-cause mortality in univariate (hazard ratio [HR]: 2.39, 95% confidence interval [CI]: 1.41-4.03
  p = 0.001) and multivariate COX regression analyses (HR: 1.78, 95%CI: 1.04-3.06
  p = 0.037). Our rapid semi-quantitative method to evaluate AAC is highly reproducible and can be used to assess AAC in patients who undergo TAVR.
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