Early vascular aging ambulatory score in acute ischemic stroke.

• Tác giả: Maurizio Acampa, Elpida Athanasopoulou, Philip M Bath, Thevoz Guillaume, Matthias Hermann, Naohisa Hosomi, Nikolaos Kakaletsis, Young Seo Kim, Eleni Korompoki, Vasilios Kotsis, Patrik Michel, Haralampos Milionis, Tomohisa Nezu, George Ntaios, Athanase D Protogerou, Jukka Putaala, Protazy Rejmer, Christos Savopoulos, Davide Strambo, Wonjae Sung, Lauri Tulkki, Konstantinos Vemmos, Lisa J Woodhouse
• Ngôn ngữ: eng
• Ký hiệu phân loại: 297.1248 Sources of Islam
• Thông tin xuất bản: England : npj aging , 2025
• Bộ sưu tập: NCBI
• ID: 493154

Tóm tắt

 Understanding the impact of early vascular aging (EVA) on acute ischemic stroke (AIS) outcomes may provide new insights for improving prognostic assessments and developing targeted therapeutic strategies. This study aimed to validate the EVA ambulatory score (EVAAs) in AIS patients, assessing its association with stroke type, severity, and prognosis. Among the 2,730 AIS patients with a mean age of 72.0 ± 14.4 years, 83.4% exhibited EVA. EVA was identified as an independent predictor of poor outcome at both discharges (aOR:1.72, 95%CI:1.25-2.36, p <
  0.001) and at 90 days (aOR:2.22, 95%CI:1.49-3.31, p <
  0.001). In subgroup analyses, EVAAs showed improved predictive value in AIS patients with a lower cardiovascular disease burden and a non-atherogenic lipid profile. The EVAAs, as an indicator of EVA that could be easily integrated into daily clinical practice, are a significant predictor of adverse outcomes in AIS patients.