This study assessed the health risks and toxicity of compounds found in the leachate and exhaust air of non-incineration devices used for hospital waste management. Specifically, it measured the levels of potentially toxic elements and pharmaceutical compounds in two disinfection waste treatment devices-hydroclave with shredder (device A) and autoclave without shredder (device B)-at a hospital in Tehran, Iran. Sampling occurred from October 2022 to March 2023. potentially toxic elements were analyzed using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES), while cytotoxicity was evaluated with an ELISA reader.The results indicated that the exhaust air from device A contained high concentrations of barium (9.80 ± 1.60 µg/m