The diagnosis and management of laryngopharyngeal reflux (LPR) remain challenging due to complex pathophysiological interactions, including autonomic nerve dysfunction and impaired esophageal motility. The lack of definitive diagnostic tools, insufficient exclusion of alternative causes, and variability in study design and methodology often lead to inconsistent treatment responses and suboptimal outcomes. Functional laryngeal disorders and hypersensitivity further complicate accurate diagnosis and management. High-resolution manometry, combined with multichannel impedance testing, has highlighted the role of esophageal dysmotility in LPR symptoms. This article focuses on the neural-mediated mechanisms and esophageal dysmotility contributing to LPR.