The influence of cell and platelet number on clinical outcomes provided by a one-step scaffold transplantation with bone marrow concentrate for the treatment of osteochondral lesions of the talus.

• Tác giả: Luca Berveglieri, Angelo Boffa, Roberto Buda, Carola Cavallo, Annarita Cenacchi, Cesare Faldini, Giuseppe Filardo, Laura Ramponi, Francesca Vannini
• Ngôn ngữ: eng
• Thông tin xuất bản: France : Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons , 2025
• Bộ sưu tập: NCBI
• ID: 493442

Tóm tắt

 PURPOSE: The aim of this study was to investigate if the numbers of cells and platelets in the bone marrow aspirate concentrate (BMAC) added to a hyaluronic acid membrane influence the clinical outcome up to long-term follow-up in the treatment of osteochondral lesions of the talus (OLTs). METHODS: A total of 102 patients with symptomatic OLTs underwent this one-step treatment. Eighty-five patients (53 men, 32 women, age 32.3 ± 10.6 years, lesion size 2.7 ± 1.6 cm RESULTS: The AOFAS improved from baseline (59.1 ± 13.7) to the final follow-up (82.3 ± 14.9, p <
  0.0005). NRS improved from 7.1 ± 1.1 at baseline to 3.9 ± 2.8 at the final follow-up (p <
  0.0005). Tegner improved from a pre-op 2.0 median to 3.0 at the final follow-up (p <
  0.0005), not reaching the pre-injury level. MNCs and platelets in BMAC were 148.2 ± 54.2 × 10 CONCLUSION: This study demonstrated, in a large series of patients evaluated up to a long-term follow-up, that the number of MNCs and platelets present in BMAC does not influence the overall clinical outcomes in patients affected by OLTs treated with a one-step hyaluronic acid scaffold implantation augmented with BMAC. LEVEL OF EVIDENCE: IV.