Independent and joint effects of genomic and exposomic loads for schizophrenia on psychotic experiences in adolescents of European ancestry.

• Tác giả: Angelo Arias-Magnasco, Ran Barzilay, Matteo Di Vincenzo, Andrea Fiorillo, Sinan Guloksuz, Bochao Danae Lin, Thanavadee Prachason, Lotta-Katrin Pries, Bart P F Rutten, Gaia Sampogna, Jim van Os
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.8982 Diseases of nervous system and mental disorders
• Thông tin xuất bản: Germany : Schizophrenia (Heidelberg, Germany) , 2025
• Bộ sưu tập: NCBI
• ID: 493530

Tóm tắt

 This study aimed to assess the independent and joint associations of genomic and exposomic liabilities for schizophrenia with distressing psychotic experiences (PEs) and their persistence in early adolescence. The Adolescent Brain and Cognitive Development Study data from children with European ancestry were used (N = 5122). The primary outcome was past-month distressing PEs at the 3-year follow-up. Secondary outcomes were distressing PEs at varying cutoffs of persistence. Multilevel logistic regression models were used to test the associations of binary modes (>
 75th percentile) of polygenic risk score for schizophrenia (PRS-SCZ