Objectives: Evaluate the effect of hypoglycemia of Tieu Khat Ling capsule on type 2 diabetes patients who have not treated by modem drug. Subjects: 30 patients were diagnosed with type 2 diabetes according to the standard choices of modem medicine (according ADA 2014) and traditional medicine. Patient have not treated by modem drug. Methodology: A prospective study, clinical trials, before and after treatment comparing. Materials: Tieu Khat Ling capsule 0,5g with number registration VD 16401 - 12 have made in Khang Minh Pharmaceutical Joint Stock Company. Results: Tieu khat Ling capsule 0.5g improved good clinical symptoms, anthropometric indices, symptoms more eaten, more drinking, more urinate, fatigue, constipation. After 90 days of treatment: reduce fasting glucose from 8.02 +/- 0.86 mmol/l to 6.21 +/- 0.69 mmol/l (p 0.01).