Mineral dissolution in porous media coupled with single- and/or multi-phase flows is pervasive in natural and engineering systems. Dissolution modifies the physical, hydrological, and geochemical properties of the solid matrix, resulting in a complex coupling between local dissolution rate and pore-scale flow. The work reports a microfluidic approach that includes 2D reactive porous media and advanced pore flow diagnostics for the study of pore-scale dissolution in porous media with unprecedented details. The 2D microfluidic porous media, called micromodels, were fabricated in calcite by combining photolithography and wet etching, which not only offers precise control over the structural and chemical properties, but also facilitate unobstructed optical access to the pore flow, significantly improving over existing methods. We believe the work represents the first of its kind as it for the first time directly applies photolithography to calcite samples and demonstrates the use of particle image velocimetry to investigate chemical reactions in porous media. The preliminary results have revealed the crucial roles of local concentration gradients in mineral dissolution and call for reconsideration of many assumptions used in the current modeling tools, which paves the way for renewed fundamental understanding of reactive transport and improved modeling tools with better accuracy.