Obesity can mediate the occurrence of many cardiovascular metabolic diseases, such as coronary heart disease and diabetes, which will lead to a significant increase in all-cause mortality in obese people. Visceral fat refers to the excessive accumulation of adipose tissue in abdominal organs, which can lead to impaired normal function of organs. In recent years, it has been reported that probiotics can reduce obesity and visceral fat content, and some studies have put forward the opposite conclusion. In order to guide the practice of nutrition, we use Meta-analysis method to analyze these conclusions. The authors searched randomized controlled trials on the effects of oral probiotics on body weight and visceral fat content in obese people published before January 2024 in several public databases, such as PubMed, Web of Science, EMBASE, Cochrane Library and CNKI. The primary outcome was body weight, and the secondary outcomes included BMI, waist circumference, visceral fat content, and low-density lipoprotein levels. This trial has been registered in PROSPERO (CRD42024521353). A total of 8 randomized controlled trials involving 412 patients were included in this meta-analysis. Meta-analysis showed that the weight loss of the experimental group taking probiotics was significantly higher than that of the control group (P <
0.00001). The reduction of waist circumference in the experimental group taking probiotics was significantly different from that in the control group (P = 0.01). The decrease of visceral fat content in the experimental group taking probiotics was significantly different from that in the control group (P <
0.00001). There was no significant difference in BMI and LDL-C levels between the experimental group and the control group. Oral probiotics can reduce weight loss, waist circumference and visceral fat content in obese patients, which may be a potential nutritional treatment for obese patients in the future. However, whether oral probiotics can reduce BMI and LDL-C levels in obese patients needs to be included in more RCTs and further discussed in the future.