A short-term, high-caloric diet has prolonged effects on brain insulin action in men.

• Tác giả: Andreas L Birkenfeld, Corinna Dannecker, Andreas Fritsche, Robert Hauffe, Martin Heni, André Kleinridders, Nils B Kroemer, Anne Kühnel, Stephanie Kullmann, Jürgen Machann, Hubert Preissl, Leontine Sandforth, Nobert Stefan, Ralf Veit, Lore Wagner
• Ngôn ngữ: eng
• Ký hiệu phân loại: 691.99 Adhesives and sealants
• Thông tin xuất bản: Germany : Nature metabolism , 2025
• Bộ sưu tập: NCBI
• ID: 494277

Tóm tắt

Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insulin action that outlasted the time-frame of its consumption in healthy weight men. Hence, brain response to insulin can adapt to short-term changes in diet before weight gain and may facilitate the development of obesity and associated diseases.