The secondary metabolites of the alga-derived fungus Aspergillus niveoglaucus КММ 4176 and their antimicrobial and antibiofilm activities.

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Tác giả: Alexandr S Antonov, Viktoria E Chausova, Artur R Chingizov, Ekaterina A Chingizova, Marina P Isaeva, Yuliya V Khudyakova, Natalya N Kirichuk, Elena V Leshchenko, Mikhail V Pivkin, Roman S Popov, Nadezhda P Shlyk, Anton N Yurchenko, Ekaterina A Yurchenko

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : The Journal of antibiotics , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 494432

Marine alga-derived fungal strain КММ 4176 was identified as Aspergillus niveoglaucus based on ITS region BenA, CaM and RPB2 gene sequence analysis. The anthraquinone derivatives emodin anthrone (1) and 4-hydroxyemodin anthrone (2), chromone derivative aloesone (3), and indole diketopiperazine alkaloid neoechinulin B (4) were isolated from the ethyl acetate extract of this fungus. In addition, UPLC MS data analysis of the KMM 4176 extract showed the presence of 17 echinulin-family alkaloids, as well as their biogenetic precursor cyclo(L-alanyl-L-tryptophyl) and a number of polyketide compounds. Emodin anthrone and 4-hydroxyemodin anthrone were found as inhibitors of biofilm formation by Staphylococcus aureus with half-maximal inhibitory concentrations (IC
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