Six Sigma and DMAIC methodology are potent quality improvement tools that can significantly improve healthcare processes. This article provides an overview of the DMAIC framework and demonstrates its application in improving procedures for physicians performing laser resurfacing and tattoo removal procedures. This methodology begins with defining clear objectives and assembling a dedicated team, followed by measuring and analyzing Critical-to-Quality variables using statistical tools. Improvement strategies are then developed and tested, with control measures implemented to ensure successful outcomes are maintained over time. By systematically following the DMAIC phases, teams can identify areas for improvement, proactively implement changes, and ultimately minimize adverse outcomes associated with medical laser procedures. Adapting the DMAIC framework for dermatological laser procedures offers a structured approach to enhance treatment effectiveness, patient satisfaction, and standardize care, ultimately reducing the risks and side effects associated with these procedures.