4-Octyl Itaconate Attenuates Postmenopausal Osteoporosis by Inhibiting Ferroptosis and Enhancing Osteogenesis via the Nrf2 Pathway.

• Tác giả: Haijun Li, Pengfei Li, Yang Li, You Li, Lei Yang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 220.52042 Modern versions and translations
• Thông tin xuất bản: United States : Inflammation , 2025
• Bộ sưu tập: NCBI
• ID: 494500

Tóm tắt

Bone marrow mesenchymal stem cells (BMSCs) play an important role in bone metabolism and tissue repair, and their ability to differentiate into osteoblasts is crucial in the treatment of bone diseases such as postmenopausal osteoporosis (PMOP). However, the function of BMSCs may be affected by ferroptosis. Ferroptosis is a cell death mode characterized by excess Fe