Mức độ khả thi, an toàn và hiệu quả của chế độ ăn ketogenic trên bệnh nhân động kinh kháng thuốc tại Bệnh viện Nhi Đồng 2

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Quang Vinh Bùi, Thị Hồng Thanh Lê, Trần Ánh Ngân Lê, Lê Trung Hiếu Nguyễn, Thị Thu Hậu Nguyễn, Thụy Minh Thư Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại: 616.853 Epilepsy

Thông tin xuất bản: Tạp chí Y học TP. Hồ Chí Minh, 2021

Mô tả vật lý: 145-151

Bộ sưu tập: Metadata

ID: 494680

Thêm vào giỏ

According to World Health Organization 2019, there are more than 50 million people worldwide suffer from epilepsy. Approximately 30% of epilepsy patients will develop drug resistance. Many studies show that the ketogenic diet is effective in patients with drug-resistant epilepsy, but there is no studies in Vietnam. To determine the percentage of the pediatric patients on the ketogenic diet, the incidence of side effects, rate of reduction in epilepsy state, duration of seizures, and frequency of seizures. Methods: Descriptive prospective study, series of cases. Children with West syndrome, Dravet syndrome and tuberous sclerosis with drug-resistant epilepsy are indicated to apply a ketogenic diet for treatment at Children's Hospital 2, from September, 2019 to July, 2020. Results: 29 pediatric patients, including 8 patients with West syndrome, 8 Dravet's syndrome and 13 tuberous sclerosis. The feasibility was 93.5%. Tolerance rates were 75.86% (1 month), and 62.07% (3 months). The incidence of adverse events was 44.8%, with mild severity. The average duration of seizures is 5.68 minutes (initial) and 1.42 minutes (after 3 months). There was 37.9% of patients was decreased >
50% of seizures after 3 months applying ketogenic diet. Conclusion: Ketogenic diet is highly feasible, safe and efficiency on the children suffered West syndrome, Dravet's syndrome, tuberous sclerosis and drug-resistant epilepsy.Theo Tổ Chức Y Tế Thế Giới năm 2019, hiện có hơn 50 triệu bệnh nhân động kinh. Khoảng 30% bệnh nhân động kinh sẽ kháng thuốc. Nhiều nghiên cứu thấy chế độ ăn ketogenic có hiệu quả trên bệnh nhân động kinh kháng thuốc, nhưng chưa có nghiên cứu nào ở Việt Nam. Xác định tỷ lệ bệnh nhi thực hiện được chế độ ăn ketogenic, tỷ lệ các tác dụng phụ, tỷ lệ giảm tần suất cơn động kinh. Đối tượng - Phương pháp nghiên cứu: Nghiên cứu mô tả hàng loạt ca, tiền cứu trên bệnh nhi hội chứng West, hội chứng Dravet và u xơ củ bị kháng thuốc, điều trị bằng chế độ ăn ketogenic tại bệnh viện Nhi Đồng 2, từ 9/2019 đến 7/2020. Kết quả: 29 bệnh nhi (8 bệnh nhi hội chứng West, 8 hội chứng Dravet và 13 u xơ củ). Tỷ lệ bệnh nhi ăn ketogenic là 93,5%. Tỷ lệ dung nạp là 75,86% (1 tháng) và 62,07% (3 tháng). Tỷ lệ tác dụng phụ là 44,8%, tuy nhiên đều nhẹ. Thời gian trung bình cơn động kinh là 5,68 phút (ban đầu) và 1,42 phút (3 tháng). 37,9% bệnh nhân giảm hơn 50% cơn động kinh sau 3 tháng. Kết luận: Chế độ ăn ketogenic có tính khả thi, an toàn và hiệu quả trên bệnh nhân hội chứng West, Dravet, u xơ củ bị động kinh kháng thuốc.

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