BACKGROUND: To differentiate inoperable non-small cell lung cancer (NSCLC) subtypes by mono-exponential (MEM), bi-exponential (BEM), and stretched- exponential models (SEM) intravoxel incoherent motion (IVIM), and MATERIALS AND METHODS: A total of 106 cases of NSCLC were included in this analysis, of which 68 cases were adenocarcinoma (AC) and 38 cases were squamous cell carcinoma (SCC). MEM derived parameter ADC
BEM derived parameters D, D*, and f, SEM derived parameters α, DDC
and RESULTS: SUV CONCLUSION: The stage, ADC, and TLG were independent predictors for differentiating subtypes of inoperable NSCLC, and when combined they showed optimal diagnostic performance and could be a superior imaging marker.