STATEMENT OF PROBLEM: Deficient hygiene of maxillofacial prostheses can be a source of infection, and various disinfectants, including nano-oxides, have been suggested for the disinfection of silicone prostheses. While maxillofacial silicones involving nano-oxides at different sizes and concentrations have been evaluated in terms of their mechanical and physical properties, reports are lacking on the antimicrobial effect of nano titanium dioxide (TiO PURPOSE: The purpose of this in vitro study was to evaluate the antimicrobial effects of 6 different disinfectants and nano TiO MATERIAL AND METHODS: A total of 258 silicone specimens (129 pure silicones and 129 nano TiO RESULTS: Significant difference was found among disinfectants regardless of the silicone type (P<
.05). Nano TiO CONCLUSIONS: The tested disinfectants and nano TiO