PURPOSE: To evaluate the outcomes of retinoblastoma (RB) based on the 8 DESIGN: Retrospective, multicenter, intercontinental, collaborative study. PARTICIPANTS: A total of 1411 patients. INTERVENTION: Primary enucleation with or without adjuvant chemotherapy or radiotherapy. MAIN OUTCOME MEASURES: Orbital tumor recurrence, tumor-related metastasis, and tumor-related death. RESULTS: According to the 8 CONCLUSIONS: The 8 FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.